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Curr Pharm Des 20:11261135 Skorjanec S, Kokot A, Drmic D et al (2015) Duodenocutaneous fistula in rats as a model for wound healing-therapy in ulcer healing: the effect of pentadecapeptide BPC 157, l-nitro-arginine methylester and l-arginine

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A lack of thyroid hormones causes a stressful physiological environment, leading to cortisol and epinephrine secretion via the hypothalamuspituitaryadrenal gland (HPA) axis

(2017) demonstrated this also in reverse: when they blocked this receptor with a selective inhibitor (SU5416), BPC-157 lost its pro-regenerative effect

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This difference explains why stem cell and peptide therapy are increasingly considered a combined strategy